Institute of Bioinformatics and Systems Biology

Organization profile

organization profile

The NCTU Bioinformatics and Systems Biology Institute is the first Institute of Bioinformatics and is ranked among the best in Taiwan, as evidenced by the excellence of the faculty and students as well as the quality of interdisciplinary educational programs. The Major is designed for highly motivated students interested in interdisciplinary activities in life sciences, computer science, statistics, systems biology, and computational biology. Leading the Institute's research and teaching activities are 10 professors and 5 core facilities (e.g. over 300-cpu PC clusters and 40 MAC computers). The Institute has over 28 and 40 graduate students pursuing master and doctorate degrees, respectively.
The NCTU Institute of Bioinformatics and Systems Biology carries out research in structural bioinformatics, systems biology (e.g. gene networks and metabolic pathways), drug discovery, biological databases and algorithms, molecular evolution, computational chemistry, and functional genomics. Supporting by National Science Council and Ministry of Education, the Institute has installed the sole Structural Bioinformatics and Computer-aided Drug Design Core Facilities. On average, each faculty publishes 5 papers/year and the sum of impact factor is over 20/year; and the grant is over 3,000,000/year. These Principle Investigators have produced renowned computational packages and databases: GEMDOCK, for drug design; 3D-BLAST, for a super fast structure database search; miRNAMap, genomic maps of microRNAs in mammalian genomes; and CELLO, for sub-cellular localization prediction.
The Molecular Bioinformatics Center (MBC) was established in 2006 as a national resource for bioinformatics and computational systems biology in Taiwan. MBC performs research in computational biology, develops software tools and novel algorithms for analyzing biological data and creates public databases. The research areas cover protein structure prediction and classification, computational drug docking, protein thermostability prediction, data mining, RNA secondary structure prediction and large-scale genomic sequence alignment.

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  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects

    從患者個體至單細胞之癌症聚焦網路應用於開發個人化生物標記及癌症治療(2/5)

    Lin, C.

    1/09/2031/08/21

    Project: Government MinistryMinistry of Science and Technology

    利用分子模擬和結構機械統計學習分析三端修復外切核酸酶1所具特有活性之分子機制(1/3)

    Chu, J.

    1/08/2031/07/21

    Project: Government MinistryMinistry of Science and Technology

    腦機介面系統於智慧控制下肢復健機提升神經回饋復健功效

    Ko, L.

    1/08/2031/07/21

    Project: Government MinistryMinistry of Science and Technology

    Research Output

    ABL genomic editing sufficiently abolishes oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo

    Chen, S. H., Hsieh, Y. Y., Tzeng, H. E., Lin, C. Y., Hsu, K. W., Chiang, Y. S., Lin, S. M., Su, M. J., Hsieh, W. S. & Lee, C. H., Jun 2020, In : Cancers. 12, 6, 1399.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    An integrated genomic strategy to identify CHRNB4 as a diagnostic/prognostic biomarker for targeted therapy in head and neck cancer

    Chuang, Y. H., Lee, C. H., Lin, C. Y., Liu, C. L., Huang, S. H., Lee, J. Y., Chiu, Y. Y., Lee, J. C. & Yang, J. M., May 2020, In : Cancers. 12, 5, 1324.

    Research output: Contribution to journalArticle

    Open Access
  • A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors

    Hsu, K-C., HuangFu, W-C., Lin, T. E., Chao, M-W., Sung, T-Y., Chen, Y-Y., Pan, S-L., Lee, J-C., Tzou, S-C., Sun, C-M. & Yang, J-M., 29 Jun 2020, In : Scientific reports. 10, 1, 12 p.

    Research output: Contribution to journalArticle

    Activities

    • 3 Editorial work
    • 2 Invited talk

    IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING (Event)

    Li-Wei Ko (Member of editorial board)

    1 Jan 201831 Dec 2018

    Activity: Publication peer-review and editorial workEditorial work

    Scientific Reports (Event)

    Jinn-Moon Yang (Member of editorial board)

    1 Jan 201722 Dec 2018

    Activity: Publication peer-review and editorial workEditorial work

    PLoS One (Event)

    Jinn-Moon Yang (Member of editorial board)

    1 Jan 201731 Dec 2018

    Activity: Publication peer-review and editorial workEditorial work